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1

Process design and optimisation for the continuous manufacturing of Nevirapine, an Active Pharmaceutical Ingredient (API) for H.I.V. treatment

Diab, Samir, McQuade, D. Tyler, Gupton, B. Frank, Gerogiorgis, Dimitrios I.

Journal:

Organic Process Research & Development

Year:

2019

Language:

english

File:

PDF, 6.11 MB

english, 2019

2

More than just a support: Graphene as a solid-state ligand for palladium-catalyzed cross-coupling reactions

Yang, Yuan, Reber, Arthur C., Gilliland, Stanley E., Castano, Carlos E., Gupton, B. Frank, Khanna, Shiv N.

Journal:

Journal of Catalysis

Year:

2018

Language:

english

File:

PDF, 1.98 MB

english, 2018

3

High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine

Yu, Eric, Mangunuru, Hari P R, Telang, Nakul S, Kong, Caleb J, Verghese, Jenson, Gilliland III, Stanley E, Ahmad, Saeed, Dominey, Raymond N, Gupton, B Frank

Journal:

Beilstein Journal of Organic Chemistry

Year:

2018

Language:

english

File:

PDF, 371 KB

english, 2018

4

Improved Synthesis of Mono- and Disubstituted 2-Halonicotinonitriles from Alkylidene Malononitriles

Longstreet, Ashley R., Campbell, Brian S., Gupton, B. Frank, McQuade, D. Tyler

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 432 KB

english, 2013

5

Microwave-assisted synthesis of Pd nanoparticles supported on Fe3O4, Co3O4, and Ni(OH)2nanoplates and catalysis application for CO oxidation

Elazab, Hany A., Moussa, Sherif, Gupton, B. Frank, El-Shall, M. Samy

Journal:

Journal of Nanoparticle Research

Year:

2014

Language:

english

File:

PDF, 1.92 MB

english, 2014

6

The continuous synthesis and application of graphene supported palladium nanoparticles: a highly effective catalyst for Suzuki-Miyaura cross-coupling reactions

Brinkley, Kendra W., Burkholder, Michael, Siamaki, Ali R., Belecki, Katherine, Gupton, B. Frank

Journal:

Green Processing and Synthesis

Year:

2015

Language:

english

File:

PDF, 565 KB

english, 2015

7

Controlled Synthesis of Silica Capsules: Taming the Reactivity of SiCl 4 Using Flow and Chemistry

Miller, L. Zane, Steinbacher, Jeremy L., Houjeiry, Tania I., Longstreet, Ashley R., Woodberry, Kendra L., Gupton, B. Frank, Chen, Banghao, Clark, Ron, McQuade, D. Tyler

Journal:

Journal of Flow Chemistry

Year:

2012

Language:

english

File:

PDF, 7.99 MB

english, 2012

8

High throughput photo-oxidations in a packed bed reactor system.

Kong, Caleb J., Fisher, Daniel, Desai, Bimbisar K., Yang, Yuan, Ahmad, Saeed, Belecki, Katherine, Gupton, B. Frank

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

9

Palladium-Catalyzed C-H Amination of C(sp 2 ) and C(sp 3 )-H Bonds: Mechanism and Scope for N-Based Molecule Synthesis

Timsina, Yam N., Gupton, B. Frank, Ellis, Keith C.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

10

Microwave-assisted synthesis of palladium nanoparticles supported on graphene: A highly active and recyclable catalyst for carbon–carbon cross-coupling reactions

Ali R. Siamaki, Abd El Rahman S. Khder, Victor Abdelsayed, M. Samy El-Shall, B. Frank Gupton

Journal:

Journal of Catalysis

Year:

2011

Language:

english

File:

PDF, 1.83 MB

english, 2011

11

Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

James C. Powers, B.Frank Gupton, A.Dale Harley, Norikazu Nishino, Ronald J. Whitley

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1977

Language:

english

File:

PDF, 731 KB

english, 1977

12

Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis

Stephanie L. Gupton, Frank B. Gertler

Journal:

Developmental Cell

Year:

2010

Language:

english

File:

PDF, 1.77 MB

english, 2010

13

Pd-Partially Reduced Graphene Oxide Catalysts (Pd/PRGO): Laser Synthesis of Pd Nanoparticles Supported on PRGO Nanosheets for Carbon–Carbon Cross Coupling Reactions

Moussa, Sherif, Siamaki, Ali R., Gupton, B. Frank, El-Shall, M. Samy

Journal:

Year:

2012

Language:

english

File:

PDF, 4.92 MB

english, 2012

14

Palladium nanoparticles supported on carbon nanotubes from solventless preparations: versatile catalysts for ligand-free Suzuki cross coupling reactions

Siamaki, Ali R., Lin, Yi, Woodberry, Kendra, Connell, John W., Gupton, B. Frank

Journal:

Journal of Materials Chemistry A

Year:

2013

Language:

english

File:

PDF, 1020 KB

english, 2013

15

Highly efficient and magnetically recyclable graphene-supported Pd/Fe3O4 nanoparticle catalysts for Suzuki and Heck cross-coupling reactions

Elazab, Hany A., Siamaki, Ali R., Moussa, Sherif, Gupton, B. Frank, El-Shall, M. Samy

Journal:

Applied Catalysis A: General

Year:

2015

Language:

english

File:

PDF, 4.89 MB

english, 2015

16

A Convergent Approach to the Total Synthesis of Telmisartan via a Suzuki Cross-Coupling Reaction between Two Functionalized Benzimidazoles

Martin, Alex D., Siamaki, Ali R., Belecki, Katherine, Gupton, B. Frank

Journal:

Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

17

Selective N -Chelation-Directed C–H Activation Reactions Catalyzed by Pd(II) Nanoparticles Supported on Multiwalled Carbon Nanotubes

Korwar, Sudha, Brinkley, Kendra, Siamaki, Ali R., Gupton, B. Frank, Ellis, Keith C.

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 861 KB

english, 2015

18

ChemInform Abstract: Selective N-Chelation-Directed C-H Activation Reactions Catalyzed by Pd(II) Nanoparticles Supported on Multiwalled Carbon Nanotubes.

Korwar, Sudha, Brinkley, Kendra, Siamaki, Ali R., Gupton, B. Frank, Ellis, Keith C.

Journal:

Year:

2015

File:

PDF, 24 KB

2015

19

ChemInform Abstract: Improved Synthesis of Mono- and Disubstituted 2-Halonicotinonitriles from Alkylidene Malononitriles.

Longstreet, Ashley R., Campbell, Brian S., Gupton, B. Frank, McQuade, D. Tyler

Journal:

Year:

2014

File:

PDF, 28 KB

2014

20

ChemInform Abstract: A Convergent Approach to the Total Synthesis of Telmisartan via a Suzuki Cross-Coupling Reaction Between Two Functionalized Benzimidazoles.

Martin, Alex D., Siamaki, Ali R., Belecki, Katherine, Gupton, B. Frank

Journal:

Year:

2015

File:

PDF, 15 KB

2015

21

CuPd Nanoparticles as Catalyst in Carbon-Carbon Cross-Coupling Reactions by Facile Oleylamine Synthesis

Smith, Sarah E, Siamaki, Ali R, Gupton, Frank, Carpenter, Everett

Journal:

Year:

2016

Language:

english

File:

PDF, 1.06 MB

english, 2016

22

Rh-catalysed asymmetric conjugate addition of boronic acids to nitroalkenes employing a P-chiral P,π-hybrid ligand

Sieber, Joshua D., Rivalti, Daniel, Herbage, Melissa A., Masters, James T., Fandrick, Keith R., Fandrick, Daniel R., Haddad, Nizar, Lee, Heewon, Yee, Nathan K., Gupton, B. Frank, Senanayake, Chris H.

Journal:

Organic Chemistry Frontiers

Year:

2016

Language:

english

File:

PDF, 1.58 MB

english, 2016

23

A Fundamental Analysis of Enhanced Cross–Coupling Catalytic Activity for Palladium Clusters on Graphene Supports.

Yang, Yuan, Castano, Carlos Eduardo, Gupton, Frank, Reber, Arthur C., Khanna, Shiv N

Journal:

Year:

2016

Language:

english

File:

PDF, 1.64 MB

english, 2016

24

A flow-based synthesis of telmisartan

Martin, Alex D., Siamaki, Ali R., Belecki, Katherine, Gupton, B. Frank

Journal:

Journal of Flow Chemistry

Year:

2015

Language:

english

File:

PDF, 109 KB

english, 2015

25

Asymmetric One-Pot Synthesis of (3 R ,3a S ,6a R )-Hexahydrofuro[2,3- b ]furan-3-ol: A Key Component of Current HIV Protease Inhibitors

Sevenich, Adrian, Liu, Gong-Qing, Arduengo, Anthony J., Gupton, B. Frank, Opatz, Till

Journal:

Journal of Organic Chemistry

Year:

2017

Language:

english

File:

PDF, 541 KB

english, 2017

26

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Longstreet, Ashley R, Opalka, Suzanne M, Campbell, Brian S, Gupton, B Frank, McQuade, D Tyler

Journal:

Beilstein Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 919 KB

english, 2013

27

Kirk-Othmer Encyclopedia of Chemical Technology || Pharmaceuticals, Large-Scale Synthesis

Gupton, B. Frank

Year:

2000

Language:

english

File:

PDF, 320 KB

english, 2000

28

The continuous synthesis of Pd supported on Fe3O4 nanoparticles: a highly effective and magnetic catalyst for CO oxidation

Elazab, Hany A., Moussa, Sherif, Brinkley, Kendra W., Gupton, B. Frank, El-Shall, M. Samy

Journal:

Green Processing and Synthesis

Year:

2017

Language:

english

File:

PDF, 3.03 MB

english, 2017

29

The Effect of Graphene on Catalytic Performance of Palladium Nanoparticles Decorated with Fe3O4, Co3O4, and Ni (OH)2: Potential Efficient Catalysts Used for Suzuki Cross—Coupling

Elazab, Hany A., Moussa, Sherif, Siamaki, Ali R., Gupton, B. Frank, El-Shall, M. Samy

Journal:

Catalysis Letters

Year:

2017

Language:

english

File:

PDF, 2.74 MB

english, 2017

30

Increasing Global Access to the High-Volume HIV Drug Nevirapine through Process Intensification

Verghese, Jenson, Kong, Caleb, Rivalti, Daniel, Yu, Eric, Krack, Rudy, Alcazar, Jesus, Manley, Julie B., McQuade, D. Tyler, Ahmad, Saeed, Belecki, Katherine, Gupton, Frank

Journal:

Green Chemistry

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

31

Chelation-directed C–H activation/C–C bond forming reactions catalyzed by Pd( ii ) nanoparticles supported on multiwalled carbon nanotubes

Korwar, Sudha, Burkholder, Michael, Gilliland, Stanley E., Brinkley, Kendra, Gupton, B. Frank, Ellis, Keith C.

Journal:

Chemical Communications

Year:

2017

Language:

english

File:

PDF, 2.10 MB

english, 2017

32

The Application of a Continuous Grignard Reaction in the Preparation of Fluconazole

Gupton, Frank B., Korwar, Sudha, Amir, Somi, Tosso, Perrer N., Kong, Caleb J., Fadnis, Swara, Desai, Bimbisar K., Ahmad, Saeed, Telang, Nakul S., Roper, Thomas D.

Journal:

European Journal of Organic Chemistry

Year:

2017

Language:

english

File:

PDF, 1.28 MB

english, 2017

33

7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

Ziegler, Robert E., Desai, Bimbisar K., Jee, Jo-Ann, Gupton, B. Frank, Roper, Thomas D., Jamison, Timothy F.

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 794 KB

english, 2018

34

7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

Ziegler, Robert E., Desai, Bimbisar K., Jee, Jo-Ann, Gupton, B. Frank, Roper, Thomas D., Jamison, Timothy F.

Journal:

Angewandte Chemie

Year:

2018

Language:

english

File:

PDF, 722 KB

english, 2018

35

Corrigendum: 7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

Ziegler, Robert E., Desai, Bimbisar K., Jee, Jo-Ann, Gupton, B. Frank, Roper, Thomas D., Jamison, Timothy F.

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 207 KB

english, 2018

36

Donor/Acceptor Concepts for Developing Efficient Suzuki Cross-Coupling Catalysts Using Graphene Supported Ni, Cu, Fe, Pd, and Bimetallic Pd-Ni Clusters

Yang, Yuan, Reber, Arthur C, Gilliland, Stanley E., Castano, Carlos E., Gupton, B. Frank, Khanna, Shiv N.

Journal:

The Journal of Physical Chemistry C

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

37

Berichtigung: 7‐Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

Ziegler, Robert E., Desai, Bimbisar K., Jee, Jo‐Ann, Gupton, B. Frank, Roper, Thomas D., Jamison, Timothy F.

Journal:

Angewandte Chemie

Year:

2018

Language:

german

File:

PDF, 358 KB

german, 2018

38

Highly-active, graphene-supported platinum catalyst for the solventless hydrosilylation of olefins

Kong, Caleb J., Gilliland, Stanley E., Clark, Brian R., Gupton, B. Frank

Journal:

Chemical Communications

Year:

2018

Language:

english

File:

PDF, 1.85 MB

english, 2018

39

On-line Stereochemical Process Monitoring by Molecular Rotational Resonance Spectroscopy

Neill, Justin, Yang, Yuan, Muckle, Matt Thomas, Reynolds, Roger L, Evangelisti, Luca, Sonstrom, Reilly E., Pate, Brooks H., Gupton, B. Frank

Journal:

Organic Process Research & Development

Year:

2019

Language:

english

File:

PDF, 718 KB

english, 2019

40

Synthesis of 5-Fluorocytosine using 2-Cyano-2-fluoroethenolate as a Key Intermediate

Dietz, Jule-Philipp, Derstine, Brenden P., Ferenc, Dorota, Crawford, Evan T., Arduengo, Anthony J., Gupton, B. Frank, McQuade, D. Tyler, Opatz, Till

Journal:

European Journal of Organic Chemistry

Year:

2019

Language:

english

File:

PDF, 2.18 MB

english, 2019

41

Catalytically sustainable, palladium-decorated graphene oxide monoliths for synthesis in flow

Ghobadi, Sajjad, Burkholder, Michael B., Smith, Sarah E., Gupton, B. Frank, Castano, Carlos E.

Journal:

Chemical Engineering Journal

Year:

2020

Language:

english

File:

PDF, 3.23 MB

english, 2020

42

An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly

Snead, David R., McQuade, D. Tyler, Ahmad, Saeed, Krack, Rudy, Stringham, Rodger W., Burns, Justina M., Abdiaj, Irini, Gopalsamuthiram, Vijayagopal, Nelson, Ryan C., Gupton, B. Frank

Journal:

Organic Process Research & Development

Year:

2020

File:

PDF, 374 KB

2020

43

Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint Driven Innovation

Kashinath, K., Snead, David, Burns, Justina M., Stringham, Rodger W., Gupton, B. Frank, McQuade, D. Tyler

Journal:

Organic Process Research & Development

Year:

2020

File:

PDF, 263 KB

2020

44

Expanding Access to Remdesivir via an Improved Pyrrolotriazine Synthesis: Supply Centered Synthesis

Paymode, Dinesh J., Cardoso, Flavio S. P., Agrawal, Toolika, Tomlin, John W., Cook, Daniel W., Burns, Justina M., Stringham, Rodger W., Sieber, Joshua D., Gupton, B. Frank, Snead, David R.

Journal:

Organic Letters

Year:

2020

File:

PDF, 1.74 MB

2020

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